Osbpl5 Gene Summary [Mouse]
Predicted to enable cholesterol binding activity; phosphatidylserine transfer activity; and phospholipid binding activity. Predicted to be involved in phospholipid transport. Predicted to be located in endoplasmic reticulum-plasma membrane contact site and intracellular membrane-bounded organelle. Predicted to be active in cytosol and membrane. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; immune system; and notochord. Orthologous to human OSBPL5 (oxysterol binding protein like 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Osbpl5 |
| Official Name | oxysterol binding protein-like 5 [Source:MGI Symbol;Acc:MGI:1930265] |
| Ensembl ID | ENSMUSG00000037606 |
| Bio databases IDs | |
| Aliases | oxysterol binding protein-like 5 |
| Synonyms | 1110006M06Rik, OBPH1, ORP5, Osbp2, oxysterol binding protein-like 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Osbpl5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid binding
- cholesterol binding
- binding protein
- phospholipid transporter
- ligand-binding domain
- PH domain
- Pleckstrin homology-like domain
- Oxysterol-binding protein
- phosphatidylinositol binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- ototoxicity
- orofacial cleft
role in cell
- proliferation
- phosphorylation in
- invasion by
- migration
- accumulation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Endoplasmic Reticulum
- cytosol
- organelle membrane contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Osbpl5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Golgi to plasma membrane transport
- cholesterol metabolic process
- phospholipid transport
- phosphatidylserine acyl-chain remodeling
- cholesterol transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- phosphatidylserine binding
- phospholipid transporter activity
- sterol binding
- cholesterol binding
- oxysterol binding