Gng12 Gene Summary [Mouse]
Predicted to enable G-protein beta-subunit binding activity; PDZ domain binding activity; and phosphate ion binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Is active in synapse. Is expressed in cerebral cortex subventricular zone; genitourinary system; and ventricular layer. Orthologous to human GNG12 (G protein subunit gamma 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gng12 |
| Official Name | guanine nucleotide binding protein (G protein), gamma 12 [Source:MGI Symbol;Acc:MGI:1336171] |
| Ensembl ID | ENSMUSG00000036402 |
| Bio databases IDs | |
| Aliases | guanine nucleotide binding protein (G protein), gamma 12 |
| Synonyms | 2010305F15Rik, G protein subunit gamma 12, G protein subunit γ 12, G protein γ 12, guanine nucleotide binding protein (G protein), gamma 12, guanine nucleotide binding protein (G protein), γ 12, HG3A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gng12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GGL
- enzyme
- protein binding
- phosphate binding
- GGL domain
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the Gng12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- AMPK Signaling
- Androgen Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Glutamate Receptor Signaling
- Gαq Signaling
- IL-1 Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- Protein Kinase A Signaling
- Relaxin Signaling
- RhoGDI Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Nucleus
- actin filaments
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gng12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- heterotrimeric G-protein complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- G-protein beta-subunit binding
- PDZ domain binding