Spag6 Gene Summary [Mouse]
Predicted to enable microtubule binding activity. Predicted to be involved in epithelial cilium movement involved in extracellular fluid movement and plasma membrane bounded cell projection organization. Predicted to be active in acrosomal vesicle; cytoskeleton; and sperm principal piece. Orthologous to human SPAG6 (sperm associated antigen 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Spag6 |
| Official Name | sperm associated antigen 6 [Source:MGI Symbol;Acc:MGI:3040687] |
| Ensembl ID | ENSMUSG00000037708 |
| Bio databases IDs | |
| Aliases | sperm associated antigen 6 |
| Synonyms | CFAP194, CT141, FAP194, Gm13334, PF16, Repro-SA-1, Spag6l, sperm associated antigen 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spag6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- HEAT-like repeat
- Armadillo/beta-catenin-like repeats
- HEAT repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast carcinoma
- cryptorchidism
- teratoma
- germ cell neoplasia
- TCF3-PBX1 fusion positive acute lymphoblastic leukemia
role in cell
- expression in
- proliferation
- apoptosis
- G1/S phase transition
- cloning by
- Gap 0-Gap 1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- microtubules
- axonemes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spag6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cilium movement
- sperm axoneme assembly
- filopodium assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- acrosomal vesicle
- sperm principal piece
- extracellular region
- axoneme
- microtubule
Molecular Function
What the gene product does at the molecular level
- microtubule binding