Tigar Gene Summary [Mouse]
Enables fructose-2,6-bisphosphate 2-phosphatase activity. Involved in positive regulation of pentose-phosphate shunt and response to ischemia. Acts upstream of or within several processes, including fructose 2,6-bisphosphate metabolic process; negative regulation of catabolic process; and positive regulation of cardiac muscle cell apoptotic process. Located in mitochondrion. Is expressed in several structures, including brain; heart; immune system; and liver. Orthologous to human TIGAR (TP53 induced glycolysis regulatory phosphatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tigar |
| Official Name | Trp53 induced glycolysis regulatory phosphatase [Source:MGI Symbol;Acc:MGI:2442752] |
| Ensembl ID | ENSMUSG00000038028 |
| Bio databases IDs | |
| Aliases | Trp53 induced glycolysis regulatory phosphatase |
| Synonyms | 9630033F20Rik, C12orf5, FR2BP, TP53 induced glycolysis regulatory phosphatase, Trp53 induced glycolysis regulatory phosphatase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tigar often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- fructose-2,6-bisphosphate 2-phosphatase
- enzyme
- protein binding
- alpha-ribazole phosphatase
- Histidine phosphatase domain
Pathways
Biological processes and signaling networks where the Tigar gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- neoplasia
- gestational diabetes mellitus
- metastasis
- vertigo
- childhood acute lymphoblastic leukemia
- acute lymphoblastic leukemia
role in cell
- migration
- invasion by
- activation in
- expression in
- proliferation
- quantity
- phosphorylation in
- apoptosis
- tubulation by
- pyroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tigar gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- glycolysis
- negative regulation of glycolysis
- fructose 2,6-bisphosphate metabolic process
- response to xenobiotic stimulus
- negative regulation of programmed cell death
- intestinal epithelial cell development
- macromitophagy
- response to DNA damage stimulus
- regulation of pentose-phosphate shunt
- reactive oxygen species metabolic process
- response to ischemia
- cardiac muscle cell apoptotic process
- glucose catabolic process to lactate via pyruvate
- positive regulation of cardiac muscle cell apoptotic process
- cellular response to cobalt ion
- cellular response to hypoxia
- response to gamma radiation
- negative regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- fructose-2,6-bisphosphate 2-phosphatase activity