TIGAR Gene Summary [Human]
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TIGAR |
| Official Name | TP53 induced glycolysis regulatory phosphatase [Source:HGNC Symbol;Acc:HGNC:1185] |
| Ensembl ID | ENSG00000078237 |
| Bio databases IDs | |
| Aliases | TP53 induced glycolysis regulatory phosphatase, TP53-induced glycolysis and apoptosis regulator |
| Synonyms | 9630033F20Rik, C12orf5, FR2BP, TP53 induced glycolysis regulatory phosphatase, Trp53 induced glycolysis regulatory phosphatase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TIGAR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- fructose-2,6-bisphosphate 2-phosphatase
- enzyme
- protein binding
- alpha-ribazole phosphatase
- Histidine phosphatase domain
Pathways
Biological processes and signaling networks where the TIGAR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- neoplasia
- gestational diabetes mellitus
- metastasis
- vertigo
- childhood acute lymphoblastic leukemia
- acute lymphoblastic leukemia
role in cell
- migration
- invasion by
- activation in
- expression in
- proliferation
- quantity
- phosphorylation in
- apoptosis
- tubulation by
- pyroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TIGAR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- glycolysis
- negative regulation of glycolysis
- fructose 2,6-bisphosphate metabolic process
- response to xenobiotic stimulus
- negative regulation of programmed cell death
- intestinal epithelial cell development
- macromitophagy
- response to DNA damage stimulus
- regulation of pentose-phosphate shunt
- reactive oxygen species metabolic process
- response to ischemia
- cardiac muscle cell apoptotic process
- glucose catabolic process to lactate via pyruvate
- positive regulation of cardiac muscle cell apoptotic process
- cellular response to cobalt ion
- cellular response to hypoxia
- response to gamma radiation
- negative regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- fructose-2,6-bisphosphate 2-phosphatase activity