Spon1 Gene Summary [Mouse]
Enables LBD domain binding activity. Acts upstream of or within negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process; and positive regulation of protein processing. Located in collagen-containing extracellular matrix. Is expressed in several structures, including aorta; craniocervical region bone; nervous system; palatal shelf; and sensory organ. Orthologous to human SPON1 (spondin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spon1 |
| Official Name | spondin 1, (f-spondin) extracellular matrix protein [Source:MGI Symbol;Acc:MGI:2385287] |
| Ensembl ID | ENSMUSG00000038156 |
| Bio databases IDs | |
| Aliases | spondin 1, (f-spondin) extracellular matrix protein |
| Synonyms | D330035F22RIK, FSP, f-spondin, MGC10724, SPONDIN 1, spondin 1, (f-spondin) extracellular matrix protein, Sponf, VSGP/F-spondin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spon1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- reelin-binding domain
- spondin domain
- Reeler domain
- Domains similar to the eukaryotic reeler domain and bacterial cohesins
- protein binding
- thrombospondin domain
- LBD domain binding
- Spondin-like TSP1 domain
- Spondin_N
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- androgenic alopecia
- COVID-19
- Alzheimer disease
- idiopathic scoliosis
- tuberculosis
- early-onset preeclampsia
- idiopathic pulmonary fibrosis
- late-onset preeclampsia
- oral squamous cell carcinoma
role in cell
- differentiation
- expression in
- activation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spon1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein processing
- protein processing
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- LBD domain binding
- metal ion binding
- extracellular matrix structural constituent