Mylip Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in several processes, including cholesterol homeostasis; negative regulation of low-density lipoprotein particle clearance; and regulation of protein catabolic process. Predicted to be located in cytoplasm; cytoskeleton; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MYLIP (myosin regulatory light chain interacting protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mylip |
| Official Name | myosin regulatory light chain interacting protein [Source:MGI Symbol;Acc:MGI:2388271] |
| Ensembl ID | ENSMUSG00000038175 |
| Bio databases IDs | |
| Aliases | myosin regulatory light chain interacting protein |
| Synonyms | 9430057C20Rik, IDOL, LOC107986517, MIR, myosin regulatory light chain interacting protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mylip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- FERM domain binding motif
- ubiquitin protein ligase activity
- central domain
- enzyme
- Ring finger domain
- protein binding
- Pleckstrin homology-like domain
- FERM N-terminal domain
- cytoskeletal protein binding
- Ubl1_cv_Nsp3_N-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- FERM domain B-lobe
- FERM C-terminal PH-like domain
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Mylip gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- organismal death
- peripheral T-cell lymphoma
- peripheral arterial disease
- lung cancer
- systemic sclerosis
- hypercholesterolemia
role in cell
- expression in
- ubiquitination in
- invasion by
- outgrowth
- migration
- development
- sumoylation in
- degradation in
- K48 polyubiquitination in
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mylip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of low-density lipoprotein particle receptor catabolic process
- protein destabilization
- negative regulation of low-density lipoprotein particle clearance
- negative regulation of neuron projection development
- nervous system development
- positive regulation of protein catabolic process
- cholesterol homeostasis
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding
- cytoskeletal protein binding