Wdfy1 Gene Summary [Mouse]
Predicted to enable 1-phosphatidylinositol binding activity. Involved in positive regulation of toll-like receptor 3 signaling pathway and positive regulation of toll-like receptor 4 signaling pathway. Located in early endosome. Is expressed in embryo; extraembryonic component; placenta; and skin. Orthologous to human WDFY1 (WD repeat and FYVE domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdfy1 |
| Official Name | WD repeat and FYVE domain containing 1 [Source:MGI Symbol;Acc:MGI:1916618] |
| Ensembl ID | ENSMUSG00000073643 |
| Bio databases IDs | |
| Aliases | WD repeat and FYVE domain containing 1 |
| Synonyms | 1700013B03Rik, 1700120F24Rik, FENS-1, Jr1, LOC108351959, mKIAA1435, SR1, WDF1, WD repeat and FYVE domain containing 1, ZFYVE17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdfy1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- WD40 repeats
- Protein present in Fab1, YOTB, Vac1, and EEA1
- WD domain, G-beta repeat
- PHD finger superfamily
- WD40
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- postmenopausal osteoporosis
regulates
- NFkB (complex)
- Shiga toxin 2
- IRF3
role in cell
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- intracellular membrane-bounded organelle
- Nucleus
- vacuole
- endosomes
- vesicles
- Golgi Apparatus
- cytosol
- nucleoli
- early endosomes
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdfy1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of toll-like receptor 3 signaling pathway
- positive regulation of toll-like receptor 4 signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- intracellular membrane-bounded organelle
- cell junction
- cytosol
- Golgi apparatus
- nucleolus
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- 1-phosphatidylinositol binding