Itln1 Gene Summary [Mouse]
Enables oligosaccharide binding activity. Involved in response to nematode. Located in brush border membrane and membrane raft. Is expressed in several structures, including brain; eye; genitourinary system; gut; and immune system. Orthologous to several human genes including ITLN1 (intelectin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itln1 |
| Official Name | intelectin 1 (galactofuranose binding) [Source:MGI Symbol;Acc:MGI:1333831] |
| Ensembl ID | ENSMUSG00000038209 |
| Bio databases IDs | |
| Aliases | intelectin 1 (galactofuranose binding) |
| Synonyms | FLJ20022, hIntL, HL-1, intelectin 1, intelectin 1 (galactofuranose binding), INTL, ITLN, Itln2, Itln3, Itln5, Itlna, Lactoferrin receptor, LFR, LOC100363780, Omentin, Omentin-1, OMNT1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itln1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium ion binding
- protein binding
- carbohydrate binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Itln1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- hyperplasia
- non-small cell lung cancer
- small cell lung cancer
- aortic valve calcification
- serous ovarian cancer
- serous ovarian adenocarcinoma
- non-insulin-dependent diabetes mellitus
regulates
- D-glucose
- AMPK
- ERK1/2
- LTF
role in cell
- proliferation
- replication in
- phosphorylation in
- growth
- signaling in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- membrane rafts
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itln1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein phosphorylation
- positive regulation of glucose import
- protein homotrimerization
- response to nematode
Cellular Component
Where in the cell the gene product is active
- extracellular space
- brush border membrane
- extracellular vesicular exosome
- membrane raft
- receptor complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- oligosaccharide binding
- identical protein binding
- protein binding
- calcium ion binding