Upf3a Gene Summary [Mouse]
Predicted to enable mRNA binding activity; protein sequestering activity; and telomeric DNA binding activity. Involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Acts upstream of or within positive regulation of mRNA cis splicing, via spliceosome and random inactivation of X chromosome. Located in neuron projection. Is expressed in central nervous system. Orthologous to human UPF3A (UPF3A regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Upf3a |
| Official Name | UPF3 regulator of nonsense transcripts homolog A (yeast) [Source:MGI Symbol;Acc:MGI:1914281] |
| Ensembl ID | ENSMUSG00000038398 |
| Bio databases IDs | |
| Aliases | UPF3 regulator of nonsense transcripts homolog A (yeast) |
| Synonyms | 2600001C03Rik, 4930546M19Rik, HUPF3A, RENT3A, UPF3, UPF3A regulator of nonsense mediated mRNA decay, UPF3A, regulator of nonsense mediated mRNA decay, UPF3 regulator of nonsense transcripts homolog A (yeast) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Upf3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- mRNA binding
- RNA recognition motif
- protein binding
- Smg-4/UPF3 family
- telomeric DNA binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Upf3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- in utero embryonic development
- spermatogenesis
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- exon-exon junction complex
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleolus
- neuron projection
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- telomeric DNA binding
- mRNA binding