Gpr88 Gene Summary [Mouse]
Enables cytoskeletal motor activity. Involved in motor learning. Acts upstream of or within locomotory behavior; neuromuscular process controlling balance; and neuronal action potential. Predicted to be located in ciliary membrane; cytoplasm; and nucleus. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and skeleton. Orthologous to human GPR88 (G protein-coupled receptor 88). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr88 |
| Official Name | G-protein coupled receptor 88 [Source:MGI Symbol;Acc:MGI:1927653] |
| Ensembl ID | ENSMUSG00000068696 |
| Bio databases IDs | |
| Aliases | G-protein coupled receptor 88 |
| Synonyms | COCPMR, G protein-coupled receptor 88, STRG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr88 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- beta2-adrenergic receptor
- seven-transmembrane G protein-coupled receptor superfamily
- motor protein
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Gpr88 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- childhood-onset chorea with psychomotor retardation
- hyperactive behavior
regulates
- 5-hydroxytryptamine
- cyclic AMP
- ADRB2
role in cell
- action potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cilia
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr88 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to light stimulus
- locomotory behavior
- G-protein coupled receptor signaling pathway
- detection of visible light
- adrenergic receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- phototransduction
- neuromuscular process controlling balance
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cilium
- cilium membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- beta2-adrenergic receptor activity
- G-protein coupled photoreceptor activity
- motor activity