Rlbp1 Gene Summary [Mouse]
Enables 11-cis retinal binding activity. Predicted to be involved in visual perception. Predicted to be located in several cellular components, including cell body; centrosome; and nucleoplasm. Is expressed in several structures, including brain; eye; foregut; spinal cord ventricular layer; and viscerocranium. Used to study Bothnia retinal dystrophy. Human ortholog(s) of this gene implicated in Bothnia retinal dystrophy; Newfoundland cone-rod dystrophy; fundus albipunctatus; night blindness; and retinitis pigmentosa. Orthologous to human RLBP1 (retinaldehyde binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rlbp1 |
| Official Name | retinaldehyde binding protein 1 [Source:MGI Symbol;Acc:MGI:97930] |
| Ensembl ID | ENSMUSG00000039194 |
| Bio databases IDs | |
| Aliases | retinaldehyde binding protein 1 |
| Synonyms | 3110056M11Rik, CRALBP, retinaldehyde binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rlbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in homologues of a S
- CRAL/TRIO, N-terminal domain
- Divergent CRAL/TRIO domain
- CRAL/TRIO domain
- 11-cis retinal binding
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Rlbp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- fundus albipunctatus
- progressive sclerosing poliodystrophy
- retinitis punctata albescens
- Bothnia retinal dystrophy
- retinal dystrophy
- Newfoundland rod-cone dystrophy
- retinitis pigmentosa
- autosomal recessive retinitis pigmentosa
- RLBP1-related retinopathy
regulates
- A1-taurine
- 11-cis-retinol
- vitamin A
- 11-cis A1 taurine
- 11-cis-retinyl esters
- 11-cis-retinal
- RHO
- all-trans A1-taurine
role in cell
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rlbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- visual perception
- vitamin A metabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- cell body
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 11-cis retinal binding
- protein binding
- retinol binding