Rdh5 Gene Summary [Mouse]
Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in retinoid metabolic process. Located in endoplasmic reticulum lumen. Is expressed in several structures, including aorta-gonad-mesonephros; central nervous system; embryo ectoderm; eye; and gut. Human ortholog(s) of this gene implicated in fundus albipunctatus and night blindness. Orthologous to human RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rdh5 |
| Official Name | retinol dehydrogenase 5 [Source:MGI Symbol;Acc:MGI:1201412] |
| Ensembl ID | ENSMUSG00000025350 |
| Bio databases IDs | |
| Aliases | retinol dehydrogenase 5 |
| Synonyms | 9-cis, 9cRDH, cRDH, HSD17B9, RDH1, RDH2, RDH4, retinol dehydrogenase 5, RoDH1, RODH5, SDR9C5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rdh5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- 3alpha(or 20beta)-hydroxysteroid dehydrogenase
- 11-cis-retinol dehydrogenase
- retinol dehydrogenase
- protein homodimerization
- 3(or 17)alpha-hydroxysteroid dehydrogenase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Rdh5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinal detachment
- preeclampsia
- retinal dystrophy
- congenital stationary night blindness
- COVID-19
- refractive error
- fundus albipunctatus
- retinopathy
- optic atrophy
- myopia
regulates
- synthetic promoter
- 11/13-cis-retinyl ester
- alitretinoin
- 9-cis-retinol
- 11-cis-retinyl esters
- 9-cis-retinal
- dihydrotestosterone
- 3-alpha,17-beta-androstanediol
- 13-cis-retinyl esters
- 13-cis-retinol
role in cell
- resensitization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
- Golgi membrane
- microsomal membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rdh5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinoid metabolic process
- retinol metabolic process
- steroid metabolic process
- visual perception
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- intracellular membrane-bounded organelle
- cell body
Molecular Function
What the gene product does at the molecular level
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- retinol dehydrogenase activity
- protein homodimerization activity
- androsterone dehydrogenase activity