Sema4a Gene Summary [Mouse]
Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Involved in several processes, including T-helper 1 cell differentiation; negative regulation of angiogenesis; and positive regulation of synapse assembly. Predicted to be active in plasma membrane. Is expressed in several structures, including blood vessel; central nervous system; primitive ventricle; retina; and ureteric trunk. Human ortholog(s) of this gene implicated in cone-rod dystrophy 10 and retinitis pigmentosa 35. Orthologous to human SEMA4A (semaphorin 4A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema4a |
| Official Name | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A [Source:MGI Symbol;Acc:MGI:107560] |
| Ensembl ID | ENSMUSG00000028064 |
| Bio databases IDs | |
| Aliases | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A |
| Synonyms | CORD10, FLJ12287, RP35, SEMAB, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A, semaphorin 4A, Semaphorin B, SEMB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- extracellular domain
- Plexin repeat
- cytoplasmic domain
- immunoglobulin domain
- ectodomain
- protein binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema4a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cone-rod dystrophy
- experimental autoimmune encephalomyelitis
- retinal dystrophy
- lung squamous cell carcinoma
- squamous cell lung cancer
- delayed hypersensitive reaction
- retinal degeneration
- Parkinson disease
- Klinefelter syndrome
- retinitis pigmentosa
role in cell
- apoptosis
- expression in
- migration
- proliferation
- cell viability
- phosphorylation in
- production in
- invasion by
- activation
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T-helper 1 cell differentiation
- regulation of cell shape
- negative regulation of angiogenesis
- regulation of endothelial cell migration
- negative chemotaxis
- neural crest cell migration
- angiogenesis
- axon guidance
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemorepellent activity
- semaphorin receptor binding