Zdhhc1 Gene Summary [Mouse]
Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of protein-containing complex assembly. Acts upstream of or within protein palmitoylation. Located in endosome membrane. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; heart; and lung. Orthologous to human ZDHHC1 (zinc finger DHHC-type containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zdhhc1 |
| Official Name | zinc finger, DHHC domain containing 1 [Source:MGI Symbol;Acc:MGI:1918046] |
| Ensembl ID | ENSMUSG00000039199 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC domain containing 1 |
| Synonyms | 4432412D04Rik, C16orf1, DHHC-1, HSU90653, zinc finger, DHHC domain containing 1, zinc finger DHHC-type containing 1, zinc finger, DHHC-type containing 1, ZNF377 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zdhhc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- protein-cysteine S-palmitoleyltransferase
- DHHC palmitoyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- infection by Herpesviridae
regulated by
- palmitic acid
role in cell
- palmitoylation in
- loss in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zdhhc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-L-cysteine S-palmitoylation
- protein palmitoylation
- positive regulation of defense response to virus by host
- protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- endoplasmic reticulum
- Golgi apparatus
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein-cysteine S-palmitoleyltransferase activity
- protein binding
- palmitoyltransferase activity