Ncdn Gene Summary [Mouse]
Involved in neuron projection development and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within bone resorption. Located in neuron projection. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; femur; and tendon. Orthologous to human NCDN (neurochondrin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncdn |
| Official Name | neurochondrin [Source:MGI Symbol;Acc:MGI:1347351] |
| Ensembl ID | ENSMUSG00000028833 |
| Bio databases IDs | |
| Aliases | neurochondrin |
| Synonyms | mKIAA0607, MMS10-AE, Ms10ae, NEDIES, neurochondrin, Norbin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncdn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Neurochondrin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with infantile epileptic spasms
- epileptic seizure
role in cell
- production in
- activation in
- binding in
- differentiation
- cell spreading
- plasticity
- formation
- endocytosis by
- signaling in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- somatodendritic region
- postsynaptic region
- cellular membrane
- vesicles
- cytosol
- endosomal membrane
- synaptic vesicles
- growth cone
- neurites
- recycling endosomes
- early endosomes
- late endosomes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncdn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- bone resorption
- regulation of neuronal synaptic plasticity
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- membrane
- cytosol
- endosome membrane
- neuronal cell body
- perikaryon
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding