Rnf122 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of mitochondrial membrane potential; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Predicted to be located in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human RNF122 (ring finger protein 122). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf122 |
| Official Name | ring finger protein 122 [Source:MGI Symbol;Acc:MGI:1916117] |
| Ensembl ID | ENSMUSG00000039328 |
| Bio databases IDs | |
| Aliases | ring finger protein 122 |
| Synonyms | 1110063C11RIK, RGD1561238, ring finger protein 122 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf122 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin protein ligase activity
- transmembrane domain
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf122 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of mitochondrial membrane potential
- positive regulation of apoptotic process
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- endoplasmic reticulum
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding