Saa3

Enables Toll-like receptor 4 binding activity and chemoattractant activity. Involved in response to stilbenoid. Acts upstream of or within several processes, including I-kappaB phosphorylation; cell chemotaxis; and cellular response to interleukin-1. Located in extracellular space. Is expressed in several structures, including cerebellum; ileum; liver; reproductive system; and thymus. Orthologous to several human genes including SAA1 (serum amyloid A1) and SAA2 (serum amyloid A2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Saa3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Saa3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.