Bmf Gene Summary [Mouse]
Involved in several processes, including cellular response to UV; negative regulation of autophagic cell death; and positive regulation of cellular component organization. Acts upstream of or within negative regulation of apoptotic signaling pathway and positive regulation of apoptotic signaling pathway. Located in actin cytoskeleton and cytoplasm. Part of myosin complex. Is expressed in brain; lung; and pituitary gland. Orthologous to human BMF (Bcl2 modifying factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmf |
| Official Name | BCL2 modifying factor [Source:MGI Symbol;Acc:MGI:2176433] |
| Ensembl ID | ENSMUSG00000040093 |
| Bio databases IDs | |
| Aliases | BCL2 modifying factor |
| Synonyms | BCL2 modifying factor, FLJ00065 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bmf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2-modifying factor, apoptosis
- Bcl-2 homology 3 domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-Hodgkin disease
- cancer
- non-insulin-dependent diabetes mellitus
- lymphatic neoplasia
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- hyperplasia
- autoimmune glomerulonephritis
role in cell
- activation in
- quantity
- cell death
- apoptosis
- growth
- molecular cleavage in
- number
- accumulation
- response
- anoikis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- Plasma Membrane
- cytosol
- mitochondrial outer membrane
- acrosome
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bmf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of autophagy
- positive regulation of release of cytochrome c from mitochondria
- positive regulation of apoptotic process
- cellular response to UV
- anoikis
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- myosin complex
- cytosol
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding