Daam2 Gene Summary [Mouse]
Predicted to enable actin binding activity and small GTPase binding activity. Involved in dorsal spinal cord development; negative regulation of oligodendrocyte differentiation; and regulation of Wnt signaling pathway. Acts upstream of or within determination of left/right symmetry. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human DAAM2 (dishevelled associated activator of morphogenesis 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Daam2 |
| Official Name | dishevelled associated activator of morphogenesis 2 [Source:MGI Symbol;Acc:MGI:1923691] |
| Ensembl ID | ENSMUSG00000040260 |
| Bio databases IDs | |
| Aliases | dishevelled associated activator of morphogenesis 2 |
| Synonyms | 2310016D11Rik, dishevelled associated activator of morphogenesis 2, dJ90A20A.1, LOC102547039, NPHS24 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Daam2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- Diaphanous FH3 Domain
- protein binding
- Diaphanous GTPase-binding Domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- nephrotic syndrome type 24
- Huntington disease
- idiopathic inflammatory myopathy
- aortic atherosclerosis
- preeclampsia
regulates
- VHL
- WNT
role in cell
- quantity
- expression in
- migration
- invasion by
- differentiation
- organization
- assembly
- migratory capacity
- invasiveness
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Daam2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of non-canonical Wnt receptor signaling pathway
- dorsal spinal cord development
- positive regulation of canonical Wnt receptor signaling pathway
- determination of left/right symmetry
- negative regulation of oligodendrocyte differentiation
- regulation of actin filament polymerization
- regulation of filopodium assembly
- regulation of actin cytoskeleton organization
- regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- actin cytoskeleton organization
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- small GTPase binding