Suco Gene Summary [Mouse]
Involved in positive regulation of collagen biosynthetic process; positive regulation of osteoblast differentiation; and regulation of bone remodeling. Located in membrane and rough endoplasmic reticulum. Is expressed in several structures, including gut; hemolymphoid system gland; liver; lung; and musculoskeletal system. Used to study osteogenesis imperfecta type 5. Orthologous to human SUCO (SUN domain containing ossification factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Suco |
| Official Name | SUN domain containing ossification factor [Source:MGI Symbol;Acc:MGI:2138346] |
| Ensembl ID | ENSMUSG00000040297 |
| Bio databases IDs | |
| Aliases | SUN domain containing ossification factor |
| Synonyms | 4732491B11, C1orf9, CH1, Dd25, OPT, SLP1, SUN domain containing ossification factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Suco often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MbeD/MobD like
- Sad1 / UNC-like C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- budesonide
- KDM1A
disease
- peripheral arterial disease
- spontaneous fracture
- dementia
phenotypes
- abnormal bone collagen fibril morphology
- abnormal bone healing
- abnormal bone ossification
- abnormal bone remodeling
- abnormal compact bone morphology
- abnormal cranium morphology
- abnormal gait
- abnormal joint morphology
- abnormal long bone morphology
- abnormal neurocranium morphology
- abnormal osteoblast morphology
- abnormal osteoblast physiology
- abnormal osteoclast physiology
- abnormal renal glomerulus morphology
- abnormal skeleton development
- abnormal skeleton physiology
- abnormal trabecular bone morphology
- decreased body size
- decreased bone mass
- decreased bone trabecula number
- decreased circulating insulin-like growth factor I level
- decreased circulating osteocalcin level
- decreased compact bone thickness
- decreased fetal size
- decreased osteoclast cell number
- decreased trabecular bone connectivity density
- decreased trabecular bone thickness
- delayed bone ossification
- delayed endochondral bone ossification
- delayed intramembranous bone ossification
- fragile skeleton
- hypoglycemia
- impaired osteoblast differentiation
- impaired righting response
- increased circulating alkaline phosphatase level
- increased osteoblast apoptosis
- increased osteocyte number
- internal hemorrhage
- neonatal lethality complete penetrance
- neonatal lethality incomplete penetrance
- postnatal growth retardation
- postnatal lethality complete penetrance
- respiratory distress
- spinal hemorrhage
- thin neurocranium
- wide cranial sutures
role in cell
- maturation
- differentiation
- synthesis in
- expansion in
- expansion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Suco gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of collagen biosynthetic process
- regulation of bone remodeling
- ossification
- positive regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- rough endoplasmic reticulum membrane
- cytoplasm
- membrane
- rough endoplasmic reticulum