Suco Gene Summary [Mouse]

Involved in positive regulation of collagen biosynthetic process; positive regulation of osteoblast differentiation; and regulation of bone remodeling. Located in membrane and rough endoplasmic reticulum. Is expressed in several structures, including gut; hemolymphoid system gland; liver; lung; and musculoskeletal system. Used to study osteogenesis imperfecta type 5. Orthologous to human SUCO (SUN domain containing ossification factor). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Suco
Official Name
SUN domain containing ossification factor [Source:MGI Symbol;Acc:MGI:2138346]
Ensembl ID
ENSMUSG00000040297
Bio databases IDs NCBI: 226551 Ensembl: ENSMUSG00000040297
Aliases SUN domain containing ossification factor
Synonyms 4732491B11, C1orf9, CH1, Dd25, OPT, SLP1, SUN domain containing ossification factor
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Suco often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • MbeD/MobD like
  • Sad1 / UNC-like C-terminal

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • peripheral arterial disease
  • spontaneous fracture
  • dementia
regulated by
regulates
role in cell
  • maturation
  • differentiation
  • synthesis in
  • expansion in
  • expansion

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cellular membrane
  • rough endoplasmatic reticulum

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Suco gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of collagen biosynthetic process
  • regulation of bone remodeling
  • ossification
  • positive regulation of osteoblast differentiation

Cellular Component

Where in the cell the gene product is active
  • rough endoplasmic reticulum membrane
  • cytoplasm
  • membrane
  • rough endoplasmic reticulum

Gene-Specific Assays for Results You Can Trust

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