Abcb1a Gene Summary [Mouse]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Abcb1a |
| Official Name | ATP-binding cassette, sub-family B (MDR/TAP), member 1A [Source:MGI Symbol;Acc:MGI:97570] |
| Ensembl ID | ENSMUSG00000040584 |
| Bio databases IDs | |
| Aliases | ATP-binding cassette, sub-family B (MDR/TAP), member 1A |
| Synonyms | Abcb1, Abcb4, ATP binding cassette subfamily B member 1A, ATP-binding cassette, sub-family B member 1A, Evi32, Mdr1a, Mdr3, P-gp, Pgy-3 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abcb1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
- carboxylic acid transporter
- efflux permease
- phospholipid transporter
- ATP binding
- Conjugate Transporter-2 (CT2) Family protein
- nitrate transport ATP-binding subunits C and D
- ATPase
- heme ABC exporter, ATP-binding protein CcmA
- energy-coupling factor transporter ATPase
- xenobiotic-transporting ATPase
- nickel import ATP-binding protein NikE
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- ATPase activity, coupled to transmembrane movement of substances
- ubiquitin protein ligase binding
- lipid A export permease/ATP-binding protein MsbA
- linker domain
- sphingolipid-translocating ATPase
- protein binding
- urea ABC transporter, ATP-binding protein UrtE
- ABC transporter transmembrane region
- lipid transporter
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- phosphatidylcholine transporter
- xenobiotic transporter
- ABC transporter
- ABC transporter, permease/ATP-binding protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- arthritis
- colitis
- inflammatory bowel disease
- pancolitis
- mucoid diarrhea
- cachexia
- chronic colitis
- drug ototoxicity - deafness
role in cell
- expression in
- cell death
- phosphorylation in
- invasion by
- quantity
- cellular infiltration by
- activation in
- transport in
- production in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- apical compartment
- cellular membrane
- intercellular junctions
- apical membrane
- membrane rafts
- brush border