Madd Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in anterograde synaptic vesicle transport; execution phase of apoptosis; and regulation of cell cycle. Acts upstream of or within negative regulation of apoptotic signaling pathway. Predicted to be located in plasma membrane and synaptic vesicle. Predicted to be active in cytosol and synapse. Is expressed in cerebral cortex; nervous system; sensory organ; and tongue. Used to study type 2 diabetes mellitus. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Madd |
| Official Name | MAP-kinase activating death domain [Source:MGI Symbol;Acc:MGI:2444672] |
| Ensembl ID | ENSMUSG00000040687 |
| Bio databases IDs | |
| Aliases | MAP-kinase activating death domain |
| Synonyms | 9630059K23Rik, DEEAH, IG20, KIAA0358, MAP-kinase activating death domain, NEDDISH, RAB3GEP, RabGEF, RabGEP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Madd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- death receptor binding
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- dDENN domain
- leucine zipper domain
- protein binding
- uDENN domain
Pathways
Biological processes and signaling networks where the Madd gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- Alzheimer disease
- respiratory failure
- migraines
- DEEAH syndrome
- hereditary disorder
- breast carcinoma
- neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia
- thyroid gland neoplasm
- head and neck neoplasia
role in cell
- expression in
- proliferation
- apoptosis
- activation in
- cell cycle progression
- quantity
- growth
- cell death
- binding in
- replication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Plasma Membrane
- cytosol
- synaptic vesicles
- neurites
- synapse
- perikaryon
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Madd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rab protein signal transduction
- regulation of extrinsic apoptotic signaling pathway
- cell surface receptor signaling pathway
- regulation of apoptotic process
- positive regulation of MAPK cascade
- regulation of cell cycle
- execution phase of apoptosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase activator activity
- guanyl-nucleotide exchange factor activity
- death receptor binding