Rcc2 Gene Summary [Mouse]
Enables small GTPase binding activity. Involved in several processes, including activation of GTPase activity; negative regulation of GTPase activity; and negative regulation of cell-substrate adhesion. Located in early endosome membrane; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Orthologous to human RCC2 (regulator of chromosome condensation 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rcc2 |
| Official Name | regulator of chromosome condensation 2 [Source:MGI Symbol;Acc:MGI:1919784] |
| Ensembl ID | ENSMUSG00000040945 |
| Bio databases IDs | |
| Aliases | regulator of chromosome condensation 2 |
| Synonyms | 2610510H01Rik, 2610529N02Rik, DKFZp762N0610, Image:3154023, mKIAA1470, regulator of chromosome condensation 2, RGD1309986, TD-60 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rcc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Regulator of chromosome condensation (RCC1) repeat
- protein kinase binding
- enzyme binding
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell cancer
- neoplasia
- epithelial neoplasia
- diffuse large B-cell lymphoma
- esophageal carcinoma
- esophageal carcinoma formation
- squamous cell lung cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- papillary renal cell carcinoma
role in cell
- apoptosis
- expression in
- proliferation
- migration
- cell proliferation
- epithelial-mesenchymal transition
- assembly
- invasion by
- migration by
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- Plasma Membrane
- midbody
- cytosol
- endosomal membrane
- nucleoli
- central spindle
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rcc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of GTPase activity
- negative regulation of substrate adhesion-dependent cell spreading
- regulation of ruffle assembly
- cell division
- negative regulation of focal adhesion assembly
- establishment of protein localization
- integrin-mediated signaling pathway
- chromosome passenger complex localization to kinetochore
- focal adhesion assembly
- positive regulation of attachment of spindle microtubules to kinetochore
- regulation of cell migration
- regulation of fibroblast migration
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- chromosome, centromeric core region
- membrane
- cytosol
- midbody
- nucleolus
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein domain specific binding
- RNA binding
- protein binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding
- microtubule binding