Ptpn21 Gene Summary [Mouse]
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human PTPN21 (protein tyrosine phosphatase non-receptor type 21). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn21 |
| Official Name | protein tyrosine phosphatase, non-receptor type 21 [Source:MGI Symbol;Acc:MGI:1344406] |
| Ensembl ID | ENSMUSG00000021009 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 21 |
| Synonyms | Bpl1, protein tyrosine phosphatase non-receptor type 21, protein tyrosine phosphatase, non-receptor type 21, PTP2E, PTPD1, PTPRL10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- protein-tyrosine-phoshatase
- Protein tyrosine phosphatase, catalytic domain
- protein binding
- Pleckstrin homology-like domain
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
- ezrin like domain
- FERM N-terminal domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- FERM domain
- Protein-tyrosine phosphatase
- Ubl1_cv_Nsp3_N-like
- phosphatase
- FERM domain B-lobe
- FERM C-terminal PH-like domain
Pathways
Biological processes and signaling networks where the Ptpn21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- dyslexia
- gastric carcinoma
- gastric epithelial cancer
- colon cancer
- pancreatic epithelial cancer
- pancreatic adenocarcinoma
- respiratory tract infectious disorder
- tinnitus
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity