Wdr43 Gene Summary [Mouse]
Enables RNA polymerase II complex binding activity and transcription elongation factor activity. Involved in regulation of stem cell population maintenance and regulation of transcription elongation by RNA polymerase II. Located in chromatin; nucleolus; and nucleoplasm. Is expressed in several structures, including alimentary system; axial musculature; clavicle; oocyte; and submandibular gland primordium. Orthologous to human WDR43 (WD repeat domain 43). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Wdr43 |
| Official Name | WD repeat domain 43 [Source:MGI Symbol;Acc:MGI:1919765] |
| Ensembl ID | ENSMUSG00000041057 |
| Bio databases IDs | |
| Aliases | WD repeat domain 43 |
| Synonyms | 2610318G08Rik, mKIAA0007, NET12, UTP5, WD repeat domain 43, Wrd43 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr43 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- transcription regulator
- WD40 repeats
- WD domain, G-beta repeat
- enzyme binding
- WD40
- protein binding
- Dip2/Utp12 Family
- transcriptional elongation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- breast carcinoma
- luminal A breast carcinoma
- luminal A breast cancer
- estrogen receptor-negative breast cancer
regulates
- rDNA
- 47S PRE-RRNA
role in cell
- processing in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- pre-ribosome
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr43 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- regulation of transcription elongation from RNA polymerase II promoter
- ribosomal small subunit biogenesis
- positive regulation of rRNA processing
- regulation of stem cell maintenance
- positive regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- nucleolus
- chromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription elongation regulator activity
- RNA binding
- protein binding
- RNA polymerase II core binding