Arhgap11a Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of GTPase activity. Predicted to be located in mitochondrial matrix and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human ARHGAP11A (Rho GTPase activating protein 11A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap11a |
| Official Name | Rho GTPase activating protein 11A [Source:MGI Symbol;Acc:MGI:2444300] |
| Ensembl ID | ENSMUSG00000041219 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 11A |
| Synonyms | 6530401L14RIK, GAP (1-12), mKIAA0013, RGD1309107, Rho GTPase activating protein 11A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap11a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- GTPase activator
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- epithelial cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- liver cancer
- thyroid carcinoma
- epithelial thyroid cancer
- rectal adenocarcinoma
role in cell
- expression in
- proliferation
- migration
- colony formation
- cell spreading
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap11a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- signal transduction
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity