Tdrkh Gene Summary [Mouse]
Predicted to enable RNA binding activity. Involved in several processes, including male meiotic nuclear division; piRNA processing; and spermatogenesis. Located in mitochondrion; pi-body; and piP-body. Is expressed in central nervous system; reproductive system; sensory organ; and urinary system. Orthologous to human TDRKH (tudor and KH domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tdrkh |
| Official Name | tudor and KH domain containing protein [Source:MGI Symbol;Acc:MGI:1919884] |
| Ensembl ID | ENSMUSG00000041912 |
| Bio databases IDs | |
| Aliases | tudor and KH domain containing protein |
| Synonyms | 2700091C21RIK, RGD1311196, TDRD2, tudor and KH domain containing, tudor and KH domain containing protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tdrkh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tudor domain
- K homology (KH) RNA-binding domain, type I
- KH domain
- protein binding
- K homology RNA-binding domain
- Tudor domain superfamily
- extended Tudor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- coronary artery disease
- distal spinal muscular atrophy
- myocardial infarction
- allergic asthma
- azoospermia
regulates
- PIWIL1
- piRNA
role in cell
- function
- abnormal morphology
- meiosis
- fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tdrkh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- male meiosis
- fertilization
- P granule organization
- piRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- P granule
- pi-body
- piP-body
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding