Cox10 Gene Summary [Mouse]
Enables protoheme IX farnesyltransferase activity. Involved in heme O biosynthetic process. Acts upstream of or within several processes, including copper ion homeostasis; heme A biosynthetic process; and mitochondrial fission. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in alimentary system; nervous system; respiratory system; and submandibular gland primordium. Used to study Parkinson's disease; cytochrome-c oxidase deficiency disease; and mitochondrial myopathy. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 3. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox10 |
| Official Name | heme A:farnesyltransferase cytochrome c oxidase assembly factor 10 [Source:MGI Symbol;Acc:MGI:1917633] |
| Ensembl ID | ENSMUSG00000042148 |
| Bio databases IDs | |
| Aliases | heme A:farnesyltransferase cytochrome c oxidase assembly factor 10 |
| Synonyms | 2410004F01RIK, AU042636, cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 10, LOC691853, MC4DN3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- enzyme
- farnesyltranstransferase
- UbiA family of prenyltransferases (PTases)
- UbiA prenyltransferase family
- protoheme IX farnesyltransferase
Pathways
Biological processes and signaling networks where the Cox10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nuclear type 3 mitochondrial complex IV deficiency
- conotruncal heart malformations
- mitochondrial disorder
- Leigh syndrome
- nuclear type 1 mitochondrial complex iv deficiency
- myopia
- paralysis
- dysmyelination
- peripheral neuropathy
regulates
- adenosine triphosphate
- MT-CO1
- lactic acid
- cytochrome-c oxidase
- heme a
- heme
- Mitochondrial ETC 1
- Cytochrome Aa3
- cytochrome
role in cell
- quantity
- respiration
- differentiation
- organization
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heme O biosynthetic process
- lipid metabolic process
- heme biosynthetic process
- heme a biosynthetic process
- aerobic respiration
- respiratory chain complex IV assembly
- mitochondrial fission
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
- cytochrome complex
- nucleolus
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protoheme IX farnesyltransferase activity
- farnesyltranstransferase activity