Foxf1 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including mesenchyme morphogenesis; regulation of transcription by RNA polymerase II; and respiratory system development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; extraembryonic component; and genitourinary system. Used to study persistent fetal circulation syndrome. Human ortholog(s) of this gene implicated in persistent fetal circulation syndrome. Orthologous to human FOXF1 (forkhead box F1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxf1 |
| Official Name | forkhead box F1 [Source:MGI Symbol;Acc:MGI:1347470] |
| Ensembl ID | ENSMUSG00000042812 |
| Bio databases IDs | |
| Aliases | forkhead box F1 |
| Synonyms | ACDMPV, AI450827, FKHL5, forkhead box F1, FOXF1A, FREAC1, HFH-8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- double-stranded DNA binding
- nucleic acid binding
- sequence-specific DNA binding
- DNA binding
- Forkhead domain
- FORKHEAD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
- alveolar rhabdomyosarcoma
- angioimmunoblastic T-cell lymphoma
- neoplasia
- cancer
- persistent fetal circulation syndrome
- hypoplasia
- diabetic nephropathy
- chorioallantoic membrane fusion failure
- idiopathic pulmonary fibrosis
role in cell
- phosphorylation in
- expression in
- apoptosis
- proliferation
- activation in
- migration
- invasion by
- transactivation in
- differentiation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial tube branching involved in lung morphogenesis
- lung lobe morphogenesis
- midgut development
- epithelial cell differentiation involved in mammary gland alveolus development
- right lung morphogenesis
- mesenchyme migration
- ductus arteriosus closure
- lung vasculature development
- embryonic ectodermal digestive tract morphogenesis
- endocardial cushion development
- embryonic digestive tract morphogenesis
- vasculogenesis
- positive regulation of transcription from RNA polymerase II promoter
- venous blood vessel development
- embryonic foregut morphogenesis
- negative regulation of mast cell degranulation
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- morphogenesis of a branching structure
- lung alveolus development
- smooth muscle cell differentiation
- blood vessel development
- in utero embryonic development
- positive regulation of transcription, DNA-dependent
- digestive tract development
- ureter development
- establishment of epithelial cell apical/basal polarity
- positive regulation of cell-substrate adhesion
- respiratory tube development
- lung development
- pancreas development
- negative regulation of inflammatory response
- trachea development
- smoothened signaling pathway
- positive regulation of mesenchymal cell proliferation
- determination of left/right symmetry
- regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
- cardiac left ventricle morphogenesis
- somitogenesis
- extracellular matrix organization
- cellular response to cytokine stimulus
- detection of wounding
- lateral mesodermal cell differentiation
- cellular response to organic cyclic compound
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity