Klhl6 Gene Summary [Mouse]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in B cell receptor signaling pathway and germinal center formation. Acts upstream of or within response to bacterium. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in blood vessel; notochord; and thymus primordium. Orthologous to human KLHL6 (kelch like family member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl6 |
| Official Name | kelch-like 6 [Source:MGI Symbol;Acc:MGI:2686922] |
| Ensembl ID | ENSMUSG00000043008 |
| Bio databases IDs | |
| Aliases | kelch-like 6 |
| Synonyms | kelch-like 6, kelch-like family member 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- duodenal-type follicular lymphoma
- follicular non-Hodgkin disease
- duodenal cancer
- hypoplasia
- B-cell non-Hodgkin lymphoma
- B-cell non-Hodgkin disease
- advanced cancer
- limited-stage typical follicular lymphoma
- advanced-stage typical follicular lymphoma
role in cell
- number
- quantity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germinal center formation
- response to bacterium
- B cell receptor signaling pathway
Molecular Function
What the gene product does at the molecular level
- protein binding