Tnfrsf17 Gene Summary [Mouse]
Predicted to enable signaling receptor activity. Acts upstream of or within lymphocyte homeostasis. Predicted to be located in membrane. Is expressed in several structures, including hemolymphoid system gland; hippocampus; male reproductive gland or organ; superior cervical ganglion; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma and multiple myeloma. Orthologous to human TNFRSF17 (TNF receptor superfamily member 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf17 |
| Official Name | tumor necrosis factor receptor superfamily, member 17 [Source:MGI Symbol;Acc:MGI:1343050] |
| Ensembl ID | ENSMUSG00000022496 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor receptor superfamily, member 17 |
| Synonyms | BCM, BCMA, BCMA antigen, CD269, TNFR4, TNF receptor superfamily member 17, Tnfrsf13, TNFRSF13A, tumor necrosis factor receptor superfamily member 17, tumor necrosis factor receptor superfamily, member 17, tumour necrosis factor receptor superfamily member 17, tumour necrosis factor receptor superfamily, member 17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfrsf17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- cytoplasmic domain
- BCMA, TALL-1 binding
- transmembrane domain
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tnfrsf17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- relapsed multiple myeloma
- epithelial cancer
- cancer
- colorectal cancer
- hepatocellular carcinoma
- psoriasis
- plasma cell myeloma
- refractory multiple myeloma
- skin cancer
- refractory relapsed multiple myeloma
role in cell
- quantity
- proliferation
- apoptosis
- expression in
- activation in
- number
- growth
- binding
- activation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear Golgi regions
- cell surface
- cell periphery
- intracellular space
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfrsf17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tumor necrosis factor-mediated signaling pathway
- signal transduction
- lymphocyte homeostasis
- adaptive immune response
Cellular Component
Where in the cell the gene product is active
- membrane
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity