Gadd45b Gene Summary [Mouse]
Acts upstream of or within negative regulation of protein kinase activity; positive regulation of MAPK cascade; and regulation of cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; embryo mesenchyme; future brain; hindlimb long bone; and sensory organ. Orthologous to human GADD45B (growth arrest and DNA damage inducible beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gadd45b |
| Official Name | growth arrest and DNA-damage-inducible 45 beta [Source:MGI Symbol;Acc:MGI:107776] |
| Ensembl ID | ENSMUSG00000015312 |
| Bio databases IDs | |
| Aliases | growth arrest and DNA-damage-inducible 45 beta |
| Synonyms | GADD45beta, Gadd45β, growth arrest and DNA-damage-inducible 45 beta, growth arrest and DNA-damage-inducible 45 β, growth arrest and DNA damage inducible beta, growth arrest and DNA-damage-inducible, beta, growth arrest and DNA damage inducible β, growth arrest and DNA-damage-inducible, β, MYD118, Myeloid differentiation primary response |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gadd45b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
- protein binding
Pathways
Biological processes and signaling networks where the Gadd45b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- lung adenocarcinoma
- non-small cell lung cancer
- COVID-19
role in cell
- growth
- expression in
- binding in
- cell death
- production in
- activation in
- phosphorylation in
- proliferation
- apoptosis
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gadd45b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JNK cascade
- apoptotic process
- positive regulation of apoptotic process
- cell differentiation
- regulation of cell cycle
- positive regulation of p38MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding