Kcnj3 Gene Summary [Mouse]
Contributes to G-protein activated inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Part of inward rectifier potassium channel complex. Is active in parallel fiber to Purkinje cell synapse and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; male reproductive gland or organ; and thymus. Orthologous to human KCNJ3 (potassium inwardly rectifying channel subfamily J member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnj3 |
| Official Name | potassium inwardly-rectifying channel, subfamily J, member 3 [Source:MGI Symbol;Acc:MGI:104742] |
| Ensembl ID | ENSMUSG00000026824 |
| Bio databases IDs | |
| Aliases | potassium inwardly-rectifying channel, subfamily J, member 3 |
| Synonyms | GIRK-1, Kcnf3, Kcnj1, KGA, KIR3.1, potassium inwardly rectifying channel subfamily J member 3, potassium inwardly-rectifying channel, subfamily J, member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnj3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol 4,5-biphosphate binding domain
- inward rectifier potassium channel
- G-protein activated inward rectifier potassium channel
- Inward rectifier potassium channel C-terminal domain
- phosphatidylinositol-4,5-bisphosphate binding
- Inward rectifier potassium channel transmembrane domain
- protein binding
- voltage-gated ion channel
- ion channel
Pathways
Biological processes and signaling networks where the Kcnj3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uveal melanoma
- ocular melanoma
- dental caries
- Alzheimer disease
- sepsis
- pulmonary emphysema
- alcoholic pancreatitis
regulates
- Ca2+
- KIR
- ion
- K+
role in cell
- function
- replication in
- depolarization in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cytoskeleton
- cell surface
- perinuclear region
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- microtubules
- plasma membrane extracellular face
- presynaptic membrane
- neurites
- secretory vesicles
- transverse tubules
- perikaryon
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnj3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- regulation of ion transmembrane transport
- regulation of heart rate by cardiac conduction
- response to electrical stimulus
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- T-tubule
- voltage-gated potassium channel complex
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein activated inward rectifier potassium channel activity
- voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization
- protein binding
- inward rectifier potassium channel activity