Trp53bp1 Gene Summary [Mouse]
Enables damaged DNA binding activity; methylated histone binding activity; and telomeric DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and positive regulation of isotype switching. Acts upstream of or within DNA repair. Located in chromosome and nuclear body. Part of DNA repair complex. Is expressed in several structures, including ileum; liver; lung; nervous system; and sensory organ. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Trp53bp1 |
| Official Name | transformation related protein 53 binding protein 1 [Source:MGI Symbol;Acc:MGI:1351320] |
| Ensembl ID | ENSMUSG00000043909 |
| Bio databases IDs | |
| Aliases | transformation related protein 53 binding protein 1 |
| Synonyms | 53BP1, LOC100502715, LOC688035, m53BP1, p202, p53BP1, TDRD30, transformation related protein 53 binding protein 1, Trp53bp1, tumor protein p53 binding protein 1, tumour protein p53 binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trp53bp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- BRCT
- transcription regulator
- transcription co-activator
- protein binding activity, bridging
- nuclear localization sequence
- transcription cofactor
- transcription factor binding
- p53 binding
- protein binding
- sequence-specific DNA binding
- kinetochore binding domain
- telomeric DNA binding
- damaged DNA binding
- BRCA1 C Terminus (BRCT) domain
- ATM phosphorylation site
- breast cancer carboxy-terminal domain
- Tudor domain superfamily
- BRCT-like domain
Pathways
Biological processes and signaling networks where the Trp53bp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- psoriatic arthritis
- cutaneous melanoma cancer
- non-Hodgkin disease
- metastasis
- lung carcinoma process
- lung cancer
- T-cell non-Hodgkin disease
- chromosomal instability
role in cell
- phosphorylation in
- apoptosis
- binding in
- formation
- formation in
- proliferation
- quantity
- survival
- growth
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nuclear foci
- nucleoplasm
- nuclear bodies
- chromatin foci
- kinetochores
- telomeres
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trp53bp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA damage checkpoint
- cellular response to X-ray
- negative regulation of double-strand break repair via homologous recombination
- positive regulation of transcription, DNA-dependent
- positive regulation of isotype switching
- protein homooligomerization
- double-strand break repair via nonhomologous end joining
- chromatin organization
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- positive regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
Where in the cell the gene product is active
- replication fork
- chromosome, telomeric region
- nucleus
- site of double-strand break
- nuclear body
- cytoplasm
- kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- transcription cofactor activity
- protein binding
- telomeric DNA binding
- histone binding
- methylated histone residue binding
- damaged DNA binding