Snx12 Gene Summary [Mouse]
Predicted to enable enzyme binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in several processes, including endosomal transport; negative regulation of protein metabolic process; and regulation of vesicle-mediated transport. Predicted to be located in early endosome. Predicted to be part of retromer complex. Predicted to be active in early endosome membrane. Is expressed in central nervous system; lung; and spleen. Orthologous to human SNX12 (sorting nexin 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snx12 |
| Official Name | sorting nexin 12 [Source:MGI Symbol;Acc:MGI:1919331] |
| Ensembl ID | ENSMUSG00000046032 |
| Bio databases IDs | |
| Aliases | sorting nexin 12 |
| Synonyms | 2610001F05Rik, AW045757, RGD1565585, SDP8, sorting nexin 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snx12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- phosphatidylinositol binding
- PX domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snx12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein transport
- negative regulation of gene expression
- negative regulation of protein processing
- protein transport
- negative regulation of early endosome to late endosome transport
- negative regulation of protein catabolic process
- late endosome to Golgi transport
- regulation of endocytosis
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- retromer complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding
- phosphatidylinositol-3-phosphate binding
- enzyme binding