Ythdf3 Gene Summary [Mouse]
Predicted to enable N6-methyladenosine-containing RNA reader activity; mRNA binding activity; and ribosome binding activity. Involved in mRNA destabilization and negative regulation of type I interferon-mediated signaling pathway. Located in cytoplasm. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; intestine; and liver. Orthologous to human YTHDF3 (YTH N6-methyladenosine RNA binding protein F3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ythdf3 |
| Official Name | YTH N6-methyladenosine RNA binding protein 3 [Source:MGI Symbol;Acc:MGI:1918850] |
| Ensembl ID | ENSMUSG00000047213 |
| Bio databases IDs | |
| Aliases | YTH N6-methyladenosine RNA binding protein 3 |
| Synonyms | 9130022A11Rik, DF3, Flj31657, YTH N6-methyladenosine RNA binding protein 3, YTH N6-methyladenosine RNA binding protein F3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ythdf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EVE and YTH domains belong to the PUA superfamily
- protein binding activity, bridging
- ribosome binding
- protein binding
- YT521-B-like domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- pancreatic cancer
- metastasis
- diffuse large B-cell lymphoma
- organismal death
- hepatocellular carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- apoptosis
- phosphorylation in
- proliferation
- production in
- binding in
- migration
- epithelial-mesenchymal transition
- degradation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- cytosol
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ythdf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational initiation
- stress granule assembly
- mRNA destabilization
- organelle assembly
- positive regulation of translation
- negative regulation of type I interferon-mediated signaling pathway
- regulation of mRNA stability
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- cytoplasm
- cytoplasmic mRNA processing body
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- ribosome binding
- mRNA binding