Zfp768 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in chromosome and nucleus. Is expressed in several structures, including cerebellum external granule cell layer; genitourinary system; neural retina; olfactory epithelium; and skeletal muscle. Orthologous to human ZNF768 (zinc finger protein 768). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp768 |
| Official Name | zinc finger protein 768 [Source:MGI Symbol;Acc:MGI:2384582] |
| Ensembl ID | ENSMUSG00000047371 |
| Bio databases IDs | |
| Aliases | zinc finger protein 768 |
| Synonyms | Zfp768, zinc finger protein 768 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp768 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- double-stranded DNA binding
- Zinc-finger double domain
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- diffuse large B-cell lymphoma
- epithelial cancer
- epithelial neoplasia
- liver cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- lymphatic neoplasia
regulated by
- doxorubicin
- RAS
- MIR3648
role in cell
- phosphorylation in
- expression in
- proliferation
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp768 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity