Frat2 Gene Summary [Mouse]
Acts upstream of or within Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human FRAT2 (FRAT regulator of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Frat2 |
| Official Name | frequently rearranged in advanced T cell lymphomas 2 [Source:MGI Symbol;Acc:MGI:2673967] |
| Ensembl ID | ENSMUSG00000047604 |
| Bio databases IDs | |
| Aliases | frequently rearranged in advanced T cell lymphomas 2 |
| Synonyms | FRAT regulator of WNT signaling pathway 2, frequently rearranged in advanced T cell lymphomas 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Frat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycogen synthase kinase-3 binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- atrial fibrillation
- migraines
- fibrosis
role in cell
- migration
- invasion by
- phosphorylation in
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Frat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- canonical Wnt receptor signaling pathway
- regulation of protein export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol