Cyb5r2 Gene Summary [Mouse]
Predicted to enable FAD binding activity and cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be involved in sterol biosynthetic process. Located in mitochondrion. Orthologous to human CYB5R2 (cytochrome b5 reductase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyb5r2 |
| Official Name | cytochrome b5 reductase 2 [Source:MGI Symbol;Acc:MGI:2444415] |
| Ensembl ID | ENSMUSG00000048065 |
| Bio databases IDs | |
| Aliases | cytochrome b5 reductase 2 |
| Synonyms | B5R.2, cytochrome b5 reductase 2, D630003K02Rik, RGD1308421 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyb5r2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- Oxidoreductase FAD-binding domain
- cytochrome-b5 reductase
- enzyme
- protein binding
- Oxidoreductase NAD-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- primary central nervous system lymphoma
- primary cancer
- lymphomagenesis
- central nervous system cancer
- early onset hypertension
regulates
- bicarbonate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyb5r2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bicarbonate transport
- sterol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- mitochondrion
- membrane
Molecular Function
What the gene product does at the molecular level
- FAD binding
- cytochrome-b5 reductase activity
- protein binding