E2f2 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway by p53 class mediator; lens fiber cell apoptotic process; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; cartilage condensation; central nervous system; genitourinary system; and skin. Orthologous to human E2F2 (E2F transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | E2f2 |
| Official Name | E2F transcription factor 2 [Source:MGI Symbol;Acc:MGI:1096341] |
| Ensembl ID | ENSMUSG00000018983 |
| Bio databases IDs | |
| Aliases | E2F transcription factor 2 |
| Synonyms | 9230110J10, E2F transcription factor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse E2f2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- nucleic acid binding
- transcription activation domain
- protein binding
- Dimerization domain of E2F transcription factors
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- cyclin A-binding domain
- double-stranded DNA binding
- E2F/DP family winged-helix DNA-binding domain
- transcription factor activity
- marked box
Pathways
Biological processes and signaling networks where the E2f2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Bladder Cancer Signaling
- Breast Cancer Regulation by Stathmin1
- Cell Cycle Regulation by BTG Family Proteins
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Estrogen-mediated S-phase Entry
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- hereditary gingival fibromatosis
- insulin-dependent diabetes mellitus
- tumorigenesis
- lymphomagenesis
- nonalcoholic fatty liver disease
- ovarian cancer
- glomerulonephritis
- androgenic alopecia
role in cell
- phosphorylation in
- expression in
- apoptosis
- proliferation
- function
- growth
- cell death
- quantity
- transcription in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse E2f2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction by p53 class mediator resulting in induction of apoptosis
- regulation of transcription, DNA-dependent
- regulation of cell cycle
- positive regulation of transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- Rb-E2F complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity