Pgrmc2 Gene Summary [Mouse]
Enables heme binding activity and heme transmembrane transporter activity. Involved in heme transport. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; neural retina; pharyngo-tympanic tube; and submandibular gland primordium. Orthologous to human PGRMC2 (progesterone receptor membrane component 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgrmc2 |
| Official Name | progesterone receptor membrane component 2 [Source:MGI Symbol;Acc:MGI:1918054] |
| Ensembl ID | ENSMUSG00000049940 |
| Bio databases IDs | |
| Aliases | progesterone receptor membrane component 2 |
| Synonyms | 4631434O19RIK, 5730409G06Rik, DG6, PMBP, PROGESTERONE MEMBRANE binding, progesterone receptor membrane component 2, PUTATIVE PROGESTERONE binding |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pgrmc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- steroid hormone receptor
- Cytochrome b5-like Heme/Steroid binding domain
- protein binding
- heme binding
- heme transporter
- transporter
- steroid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cellular membrane
- Endoplasmic Reticulum
- nucleoplasm
- nuclear envelope
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pgrmc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- steroid hormone mediated signaling pathway
- heme transport
- adipose tissue development
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- membrane
- endomembrane system
- endoplasmic reticulum
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- heme transporter activity
- steroid hormone receptor activity
- steroid binding
- heme binding