Samd11 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and protein domain specific binding activity. Involved in retinal rod cell development. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PRC1 complex. Is expressed in photoreceptor layer; pineal gland; retina; retina layer; and retina outer nuclear layer. Orthologous to human SAMD11 (sterile alpha motif domain containing 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Samd11 |
| Official Name | sterile alpha motif domain containing 11 [Source:MGI Symbol;Acc:MGI:2446220] |
| Ensembl ID | ENSMUSG00000096351 |
| Bio databases IDs | |
| Aliases | sterile alpha motif domain containing 11 |
| Synonyms | MRS, RGD1310271, sterile alpha motif domain containing 11, sterile α motif domain containing 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Samd11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- SAM (Sterile alpha motif )
- SAM domain
- SAM domain (Sterile alpha motif)
- protein domain specific binding
- protein binding
- PH-domain binding
- SAND domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic inflammatory myopathy
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- reporter gene
- synthetic promoter
role in cell
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Samd11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- retinal rod cell development
Cellular Component
Where in the cell the gene product is active
- nucleus
- PRC1 complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding