Nlgn1 Gene Summary [Mouse]
Enables neurexin family protein binding activity. Involved in several processes, including positive regulation of transport; regulation of postsynapse organization; and synapse organization. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of respiratory gaseous exchange by nervous system process; and synapse organization. Located in external side of plasma membrane and synapse. Part of receptor complex. Is active in glutamatergic synapse. Is expressed in blood vessel and brain. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN1 (neuroligin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlgn1 |
| Official Name | neuroligin 1 [Source:MGI Symbol;Acc:MGI:2179435] |
| Ensembl ID | ENSMUSG00000063887 |
| Bio databases IDs | |
| Aliases | neuroligin 1 |
| Synonyms | 6330415N05Rik, BB179718, mKIAA1070, Neuroligin 1, NL1, NLG1, Similar to aconitase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nlgn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Carboxylesterase family
- signaling receptor activity
- alpha/beta hydrolases
- cell adhesion molecule binding
- O-linked glycosylation site
- protein binding
- identical protein binding
- PDZ-domain binding
- acetylcholinesterase homology domain
- binding protein
- cytoplasmic domain
- transmembrane domain
- neurexin binding
- Neurexin-1beta binding site
- PDZ binding motif
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- metastasis
- suicide attempt
- bipolar disorder
- insomnia
- non-insulin-dependent diabetes mellitus
- major depression
- metabolic syndrome X
- TCF3-PBX1 fusion positive acute lymphoblastic leukemia
- preeclampsia
role in cell
- formation
- expression in
- release
- differentiation
- adhesion
- recruitment
- outgrowth
- development
- quantity
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- synaptic cleft
- cell surface
- cellular membrane
- Golgi Apparatus
- plasma membrane extracellular face
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- synaptosomes
- synapse
- filopodia
- perikaryon
- dendrites
- postsynaptic density
- excitatory synapses
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nlgn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synaptic transmission, GABAergic
- positive regulation of neuromuscular synaptic transmission
- neuron projection morphogenesis
- heterophilic cell-cell adhesion
- positive regulation of filopodium assembly
- nervous system development
- synaptic vesicle clustering
- neuron cell-cell adhesion
- regulation of neuron differentiation
- postsynaptic membrane assembly
- cellular response to calcium ion
- synaptic vesicle endocytosis
- neuronal signal transduction
- presynaptic membrane assembly
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
- regulation of N-methyl-D-aspartate selective glutamate receptor activity
- positive regulation of synaptic transmission, glutamatergic
- protein localization to synapse
- positive regulation of synapse assembly
- negative regulation of dendritic spine morphogenesis
- calcium-dependent cell-cell adhesion
- neuron projection development
- synaptic transmission
- positive regulation of dendritic spine development
- cytoskeletal matrix organization at active zone
- positive regulation of synaptic vesicle endocytosis
- positive regulation of ruffle assembly
- receptor localization to synapse
- establishment of protein localization
- protein targeting
- synaptic vesicle targeting
- synapse assembly
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering
- rhythmic process
- neurexin clustering
- N-methyl-D-aspartate receptor clustering
- terminal button organization
- postsynaptic density protein 95 clustering
- positive regulation of circadian sleep/wake cycle, wakefulness
- regulation of synaptic transmission
- positive regulation of excitatory postsynaptic membrane potential
- positive regulation of synaptic vesicle exocytosis
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- excitatory synapse
- receptor complex
- Golgi apparatus
- synapse
- plasma membrane
- cell surface
- dendrite
- synaptic cleft
- postsynaptic membrane
- dendritic spine
- membrane
- filopodium tip
- neuromuscular junction
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- identical protein binding
- cell adhesion molecule binding
- signaling receptor activity
- neurexin family protein binding
- PDZ domain binding
- beta-amyloid binding