Nrxn2 Gene Summary [Mouse]
Enables several functions, including calcium channel regulator activity; cell adhesion molecule binding activity; and neuroligin family protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; postsynapse organization; and regulation of postsynapse assembly. Acts upstream of or within neurotransmitter secretion and synapse assembly. Part of protein-containing complex. Is active in glutamatergic synapse. Is expressed in several structures, including blood vessel; nervous system; and retina. Used to study autism spectrum disorder. Orthologous to human NRXN2 (neurexin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrxn2 |
| Official Name | neurexin II [Source:MGI Symbol;Acc:MGI:1096362] |
| Ensembl ID | ENSMUSG00000033768 |
| Bio databases IDs | |
| Aliases | neurexin II |
| Synonyms | 6430591O13RIK, LOC100503340, mKIAA0921, neurexin 2, neurexin II, Nrxn2a, NRXN2 isoform 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrxn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Concanavalin A-like lectin/glucanases superfamily
- putative band 4.1 homologues' binding motif
- LNS repeats
- LamG
- cell adhesion molecule binding
- protein binding
- receptor binding
- transmembrane receptor
- calcium channel regulator
- laminin G domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- androgenic alopecia
- dyspnea
regulates
- neurotransmitter
- voltage-gated calcium channel
- TAFA1
role in cell
- expression in
- formation
- assembly
- transmission
- morphogenesis
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrxn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- signal transduction
- vocal learning
- synaptic transmission
- neuron cell-cell adhesion
- neurotransmitter secretion
- synapse assembly
- postsynaptic membrane assembly
- gephyrin clustering
- postsynaptic density protein 95 clustering
- neuroligin clustering
- adult behavior
- vocalization behavior
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- macromolecular complex
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- metal ion binding
- cell adhesion molecule binding
- neuroligin family protein binding
- calcium channel regulator activity