Sox12 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; and spinal cord development. Part of protein-DNA complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human SOX12 (SRY-box transcription factor 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sox12 |
| Official Name | SRY (sex determining region Y)-box 12 [Source:MGI Symbol;Acc:MGI:98360] |
| Ensembl ID | ENSMUSG00000051817 |
| Bio databases IDs | |
| Aliases | SRY (sex determining region Y)-box 12 |
| Synonyms | 2010205A02RIK, SOX22, SRY-box transcription factor 12, SRY (sex determining region Y)-box 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sox12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- sequence-specific DNA binding
- DNA binding
Pathways
Biological processes and signaling networks where the Sox12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- preeclampsia
- persistent truncus arteriosus
- double outlet right ventricle
- rotator cuff injury
- ventricular septal defect
- febrile seizure
- flu
role in cell
- expression in
- proliferation
- apoptosis
- migration
- colony formation
- differentiation
- invasion by
- frequency
- sphere formation
- chondrogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sox12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of regulatory T cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- neuron differentiation
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- spinal cord development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity