P2rx7 Gene Summary [Mouse]
Enables several functions, including ATP binding activity; extracellularly ATP-gated monoatomic cation channel activity; and lipopolysaccharide binding activity. Involved in several processes, including bleb assembly; negative regulation of cell volume; and positive regulation of NLRP3 inflammasome complex assembly. Acts upstream of or within several processes, including phospholipid transport; positive regulation of cytokine production; and positive regulation of secretion. Located in several cellular components, including external side of plasma membrane; neuromuscular junction; and neuronal cell body. Is expressed in brain; cerebral cortex ventricular layer; heart; and metanephros. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | P2rx7 |
| Official Name | purinergic receptor P2X, ligand-gated ion channel, 7 [Source:MGI Symbol;Acc:MGI:1339957] |
| Ensembl ID | ENSMUSG00000029468 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2X, ligand-gated ion channel, 7 |
| Synonyms | LOC100911975, LOC108352449, P2X7, P2X(7), P2X7R, P2Z, Purinergic receptor, purinergic receptor P2X 7, purinergic receptor P2X, ligand-gated ion channel, 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse P2rx7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- extracellular domain
- sodium channel
- signaling receptor activity
- channel/pore class transporter
- ATP P2X receptor
- ATP binding
- protein binding
- receptor binding
- magnesium ion binding
- identical protein binding
- lipopolysaccharide binding
- ion channel
- protein kinase activator
- P2X purinoreceptor 7 intracellular domain
- copper ion binding
- zinc ion binding
- purinergic nucleotide receptor
- intracellular domain
- ATP-gated cation channel
Pathways
Biological processes and signaling networks where the P2rx7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- rheumatoid arthritis
- arthritis
- gout
- multiple sclerosis
- kainic acid-induced epileptic seizure
- major depression
- non-insulin-dependent diabetes mellitus
role in cell
- phosphorylation in
- expression in
- quantity
- phagocytosis by
- signaling in
- proliferation
- production in
- apoptosis
- damage
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- nuclear fraction
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- Mitochondria
- intercellular junctions
- cell-cell contacts
- plasma membrane extracellular face
- apical membrane
- plasma membrane projections
- basolateral membrane
- nuclear envelope
- neuromuscular junctions
- nerve ending
- myelin sheath
- synaptosomes
- synapse
- perikaryon
- axon terminals
- presynaptic terminals
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse P2rx7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pore complex assembly
- T cell homeostasis
- mitochondrial depolarization
- inflammatory response
- release of sequestered calcium ion into cytosol
- positive regulation of protein secretion
- calcium-mediated signaling
- response to electrical stimulus
- positive regulation of bone mineralization
- defense response to Gram-positive bacterium
- collagen metabolic process
- regulation of excitatory postsynaptic membrane potential
- purinergic nucleotide receptor signaling pathway
- cell morphogenesis
- negative regulation of bone resorption
- phospholipid transfer to membrane
- positive regulation of cytoskeleton organization
- positive regulation of gene expression
- T cell apoptotic process
- T cell mediated cytotoxicity
- sensory perception of pain
- positive regulation of T cell apoptotic process
- protein processing
- positive regulation of T cell mediated cytotoxicity
- prostaglandin secretion
- positive regulation of interleukin-6 production
- membrane depolarization
- glutamate secretion
- response to zinc ion
- negative regulation of MAPK cascade
- extrinsic apoptotic signaling pathway
- apoptotic signaling pathway
- ceramide biosynthetic process
- response to xenobiotic stimulus
- positive regulation of glycolysis
- response to mechanical stimulus
- positive regulation of prostaglandin secretion
- positive regulation of macrophage cytokine production
- MAPK cascade
- response to ischemia
- negative regulation of cell volume
- phagolysosome assembly
- NAD transport
- phospholipid scrambling
- calcium ion transmembrane transport
- cellular response to dsRNA
- positive regulation of mitochondrial depolarization
- synaptic vesicle exocytosis
- cellular response to ATP
- response to fluid shear stress
- positive regulation of ion transmembrane transport
- bleb assembly
- response to ATP
- positive regulation of gamma-aminobutyric acid secretion
- protein catabolic process
- gamma-aminobutyric acid secretion
- cell surface receptor signaling pathway
- positive regulation of MAPK cascade
- skeletal system morphogenesis
- protein secretion
- mitochondrion organization
- reactive oxygen species metabolic process
- regulation of sodium ion transport
- membrane budding
- membrane protein ectodomain proteolysis
- homeostasis of number of cells within a tissue
- response to calcium ion
- positive regulation of protein phosphorylation
- T cell proliferation
- positive regulation of interleukin-1 alpha production
- response to lipopolysaccharide
- positive regulation of calcium ion transport into cytosol
- positive regulation of interleukin-1 beta production
- positive regulation of glutamate secretion
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytoplasm
- mitochondrion
- membrane
- external side of plasma membrane
- bleb
- neuromuscular junction
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- extracellular ATP-gated cation channel activity
- ATP binding
- identical protein binding
- protein binding
- purinergic nucleotide receptor activity
- receptor binding
- lipopolysaccharide binding