Mogat2 Gene Summary [Mouse]
Enables 2-acylglycerol O-acyltransferase activity and acetyltransferase activity. Involved in triglyceride biosynthetic process. Acts upstream of or within diacylglycerol biosynthetic process and intestinal absorption. Predicted to be located in perinuclear endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; embryo endoderm; liver; metanephros; and yolk sac. Orthologous to human MOGAT2 (monoacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mogat2 |
| Official Name | monoacylglycerol O-acyltransferase 2 [Source:MGI Symbol;Acc:MGI:2663253] |
| Ensembl ID | ENSMUSG00000052396 |
| Bio databases IDs | |
| Aliases | monoacylglycerol O-acyltransferase 2 |
| Synonyms | DGAT2L5, DGAT2L5., hDC5, LOC683355, Mgat1l, MGAT2, monoacylglycerol O-acyltransferase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mogat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 2-acylglycerol O-acyltransferase
- enzyme
- acetyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- weight gain
- diabetes mellitus
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- alloxan-induced diabetic nephropathy
- nonalcoholic fatty liver disease
- fracture of bone
- hyperlipidemia
role in cell
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mogat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol metabolic process
- intestinal absorption
- triglyceride biosynthetic process
- diacylglycerol biosynthetic process
- monoacylglycerol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- acetyltransferase activity
- 2-acylglycerol O-acyltransferase activity
- diacylglycerol O-acyltransferase activity