MOGAT2 Gene Summary [Human]
The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | MOGAT2 |
| Official Name | monoacylglycerol O-acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:23248] |
| Ensembl ID | ENSG00000166391 |
| Bio databases IDs | |
| Aliases | monoacylglycerol O-acyltransferase 2 |
| Synonyms | DGAT2L5, DGAT2L5., hDC5, LOC683355, Mgat1l, MGAT2, monoacylglycerol O-acyltransferase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MOGAT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 2-acylglycerol O-acyltransferase
- enzyme
- acetyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- weight gain
- diabetes mellitus
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- alloxan-induced diabetic nephropathy
- nonalcoholic fatty liver disease
- fracture of bone
- hyperlipidemia
role in cell
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MOGAT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol metabolic process
- intestinal absorption
- triglyceride biosynthetic process
- diacylglycerol biosynthetic process
- monoacylglycerol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- acetyltransferase activity
- 2-acylglycerol O-acyltransferase activity
- diacylglycerol O-acyltransferase activity