Herc3 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Is expressed in embryo mesenchyme; esophagus; lung; nervous system; and sensory organ. Orthologous to human HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Herc3 |
| Official Name | hect domain and RLD 3 [Source:MGI Symbol;Acc:MGI:1921248] |
| Ensembl ID | ENSMUSG00000029804 |
| Bio databases IDs | |
| Aliases | hect domain and RLD 3 |
| Synonyms | 5730409F18Rik, HECT and RLD domain containing E3 ubiquitin protein ligase 3, hect domain and RLD 3, mKIAA0032 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Herc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of chromosome condensation (RCC1) repeat
- HECTc
- Domain Homologous to E6-AP Carboxyl Terminus with
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- colorectal cancer
- organismal death
role in cell
- expression in
- phosphorylation in
- proliferation
- binding in
- degradation in
- migration
- invasion by
- ubiquitination in
- K27 polyubiquitination in
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- endosomal compartment
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Herc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytoplasmic vesicle